Response to Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection"
نویسندگان
چکیده
منابع مشابه
Response to Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".
Ebselen's antivirulence activity in Clostridium difficile infection is likely due to multiple modes of action, but the contribution of each to its efficacy remains unclear.
متن کاملA small-molecule antivirulence agent for treating Clostridium difficile infection.
Clostridium difficile infection (CDI) is a worldwide health threat that is typically triggered by the use of broad-spectrum antibiotics, which disrupt the natural gut microbiota and allow this Gram-positive anaerobic pathogen to thrive. The increased incidence and severity of disease coupled with decreased response, high recurrence rates, and emergence of multiple antibiotic-resistant strains h...
متن کاملComment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".
New insights into the mechanism of action of ebselen, a small-molecule antivirulence agent that reduces disease pathology in a mouse model of Clostridium difficile infection, suggest a different molecular target may be responsible for its efficacy.
متن کاملAn agent-based simulation model for Clostridium difficile infection control.
BACKGROUND Control of Clostridium difficile infection (CDI) is an increasingly difficult problem for health care institutions. There are commonly recommended strategies to combat CDI transmission, such as oral vancomycin for CDI treatment, increased hand hygiene with soap and water for health care workers, daily environmental disinfection of infected patient rooms, and contact isolation of dise...
متن کاملTreating Clostridium difficile infection with fecal microbiota transplantation.
Clostridium difficile infection is increasing in incidence, severity, and mortality. Treatment options are limited and appear to be losing efficacy. Recurrent disease is especially challenging; extended treatment with oral vancomycin is becoming increasingly common but is expensive. Fecal microbiota transplantation is safe, inexpensive, and effective; according to case and small series reports,...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2016
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.aaf3410